CDK12 prevents MYC-induced transcription-replication conflicts [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 2 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CDK12 controls transcription at damaged genes and prevents MYC-induced transcription-replication conflictsNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236546_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA991553 and SRA study SRP447491. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE236550 CDK12 prevents MYC-induced transcription-replication conflicts [EdU-seq] 12 samples shares cdk12, transcription-replication, myc-induced, conflicts, prevents
- GSE236553 CDK12 prevents MYC-induced transcription-replication conflicts 48 samples shares cdk12, transcription-replication, myc-induced, conflicts, prevents
- GSE236545 CDK12 prevents MYC-induced transcription-replication conflicts [RNA-seq] 14 samples shares cdk12, transcription-replication, myc-induced, conflicts, prevents
- GSE236549 CDK12 prevents MYC-induced transcription-replication conflicts [EU-seq] 12 samples shares cdk12, transcription-replication, myc-induced, conflicts, prevents
- GSE309899 Targeting CDK12 disrupts estrogen-receptor chromatin recruitment and ER-MED1 transcription in advanced ER+ breast cancer [ChIP-Seq] 8 samples shares cdk12, chip-seq
- GSE328796 Targeting Cyclin K-CDK12 Synergizes with ATR Inhibition by Limiting RPA Chromatin Loading in Triple-Negative Breast Cancer [ChIP-seq] 6 samples shares cdk12, chip-seq
- GSE316746 Targeting CDK12/CYCLIN K induces a gene activation program which is mediated by P-TEFb [ChIP-seq] 2 samples shares cdk12, chip-seq
- GSE267495 Transcription-Replication conflicts are linked to histone H3K79 methylation and R-loop dependent nucleosome eviction [ChIPseq] 16 samples shares transcription-replication, conflicts
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.