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The Impact of PAD4-dependent Neutrophil Extracellular Trap formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease

GSE236655 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/14 Platform GPL28038
Summary
To explore the potential profibrotic effect of neutrophil extacellular traps (NETs), we investigated the transcriptional modification that NET stimulation determines in the intestine of patients with Crohn's disease(CD). To this end, primary intestinal fibroblasts derived from the ileum of patients with CD were either coltured with NETs for 24 hours or left untreated. Bulk RNA sequencing (RNA-seq) was performed to evaluate the differentially expressed genes and determine the possible profibrogenic signature of this interaction.
Published in
The Impact of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn's Disease
Dragoni G, Ke BJ, Picariello L et al. · Journal of Crohn's & colitis 2025 · PMID 39126198 · doi:10.1093/ecco-jcc/jjae121
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Also filed as BioProject PRJNA991982 and SRA study SRP447762. Searching any of these in the dataset finder brings you back here.

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