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Pharmacological inhibition of LIFR impairs ovarian cancer progression by blocking LIF/LIFR autocrine loop

GSE236743 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/29 Platform GPL11154
Summary
We examined the transcriptional chagnes modulated by LIFR inhibitory compound EC359 by perfroming global transcriptome analysis. ES2 cells were treated with vehicle or EC359 for 12 h and the RNA was isolated and utilized for RNA-seq analysis. Our results demonstrated that EC359 modulated unique pathways including oxidative phosphorylation, Glutathione signaling, JNK signaling, NRF2 signaling, ovarian cancer signaling, hypoxia signaling and apoptotic pathways.
Published in
Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis
Ebrahimi B, Viswanadhapalli S, Pratap UP et al. · NPJ precision oncology 2024 · PMID 38789520 · doi:10.1038/s41698-024-00612-y
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Also filed as BioProject PRJNA992123 and SRA study SRP447784. Searching any of these in the dataset finder brings you back here.

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