Herpes simplex virus type 1 reshapes the host chromatin architecture via transcription machinery hijacking [RNA-seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × Human_A549, non infected, vs 3 × Human_A549, 1 hour post infection, vs 3 × Human_A549, 3 hours post infection, vs 3 × Human_A549, 8 hours post infection,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijackingNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237079_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA993680 and SRA study SRP448614. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7594473 Human_A549, non infected, rep1 Human_A549, non infecte…
- GSM7594474 Human_A549, non infected, rep2 Human_A549, non infecte…
- GSM7594475 Human_A549, non infected, rep3 Human_A549, non infecte…
- GSM7594476 Human_A549, 1 hour post infection, rep1 Human_A549, 1 hour post…
- GSM7594477 Human_A549, 1 hour post infection, rep2 Human_A549, 1 hour post…
- GSM7594478 Human_A549, 1 hour post infection, rep3 Human_A549, 1 hour post…
- GSM7594479 Human_A549, 3 hours post infection, rep1 Human_A549, 3 hours pos…
- GSM7594480 Human_A549, 3 hours post infection, rep2 Human_A549, 3 hours pos…
- GSM7594481 Human_A549, 3 hours post infection, rep3 Human_A549, 3 hours pos…
- GSM7594482 Human_A549, 8 hours post infection, rep1 Human_A549, 8 hours pos…
- GSM7594483 Human_A549, 8 hours post infection, rep2 Human_A549, 8 hours pos…
- GSM7594484 Human_A549, 8 hours post infection, rep3 Human_A549, 8 hours pos…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.