Endothelial transcription factor EB protects against doxorubicin-induced endothelial toxicity and cardiac dysfunction
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 5 × Empty_vector_vehicle vs 5 × TFEB_vehicle vs 5 × Empty_vector_DOX vs 5 × TFEB_DOXGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endothelial Transcription Factor EB Protects Against Doxorubicin-Induced Endothelial Toxicity and Cardiac DysfunctionCirculation · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237200_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA994158 and SRA study SRP448894. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9056768 Empty_vector_vehicle_01 Empty_vector_vehicle
- GSM9056769 Empty_vector_vehicle_02 Empty_vector_vehicle
- GSM9056770 Empty_vector_vehicle_03 Empty_vector_vehicle
- GSM9056771 Empty_vector_vehicle_04 Empty_vector_vehicle
- GSM9056772 Empty_vector_vehicle_05 Empty_vector_vehicle
- GSM9056773 TFEB_vehicle_01 TFEB_vehicle
- GSM9056774 TFEB_vehicle_02 TFEB_vehicle
- GSM9056775 TFEB_vehicle_03 TFEB_vehicle
- GSM9056776 TFEB_vehicle_04 TFEB_vehicle
- GSM9056777 TFEB_vehicle_05 TFEB_vehicle
- GSM9056778 Empty_vector_DOX_01 Empty_vector_DOX
- GSM9056779 Empty_vector_DOX_02 Empty_vector_DOX
- GSM9056780 Empty_vector_DOX_03 Empty_vector_DOX
- GSM9056781 Empty_vector_DOX_04 Empty_vector_DOX
- GSM9056782 Empty_vector_DOX_05 Empty_vector_DOX
- GSM9056783 TFEB_DOX_01 TFEB_DOX
- GSM9056784 TFEB_DOX_02 TFEB_DOX
- GSM9056785 TFEB_DOX_03 TFEB_DOX
- GSM9056786 TFEB_DOX_04 TFEB_DOX
- GSM9056787 TFEB_DOX_05 TFEB_DOX
- GSE314310 Cardiopedia-Ligand: a Ligand Stimulation Atlas for Cardiac Function and Transcriptional Response 468 samples shares transcription, cardiac
- GSE242299 Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype 31 samples shares transcription, endothelial
- GSE307817 A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease 12 samples shares transcription, endothelial
- GSE275647 Role of Cancer-Associated Fibroblasts in Prognostic Stratification of Advanced-Stage Gastric Cancer through Interacting with Endothelial and Malignant Epithelial Cells [AGC RNA-seq] 216 samples shares endothelial
- GSE271676 Spatial Transcriptional Landscape of Human Heart Failure 178 samples shares transcription
- GSE274546 The Multi-Layered Transcriptional Architecture of Glioblastoma Ecosystems [10X] 121 samples shares transcription
- GSE178411 Whole-transcriptome analysis illustrates evolving transcriptional human response to injury in acute wounds and scars 108 samples shares transcription
- GSE254249 Remodeling of T and endothelial cells during total neoadjuvant therapy in rectal cancer 92 samples shares endothelial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.