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IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T-cell engager immunotherapy in solid tumors

GSE237266 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/04/16 Platform GPL21273
Summary
Bispecific T-cell engagers (TCEs) show promising clinical efficacy in blood tumors, but their application to solid tumors with immunosuppressive environments remains challenging. Here, we show that Fc-fused IL-7 (rhIL-7-hyFc) changes the intratumoral CD8 T cell landscape, allowing TCE-immunotherapy to function effectively in solid tumors. In order to explore the transcriptomic changes induced by rhIL-7-hyFc or a combination of rhIL-7-hyFc and TCE treatment at the clonal level, we performed scRNA/TCR-seq.
Published in
IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy
Lee KJ, Choi D, Tae N et al. · Cell reports. Medicine 2024 · PMID 38744277 · doi:10.1016/j.xcrm.2024.101567
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Also filed as BioProject PRJNA994499 and SRA study SRP449365. Searching any of these in the dataset finder brings you back here.

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