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Transcription-Associated Chromatin Reorganization During Cellular Rejuvenation (RNA-Seq)

GSE237269 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/20 Platform GPL15520
Summary
Aging is associated with a progressive decline in cellular function. To reset the aged cellular phenotype, various reprogramming approaches, including mechanical routes, have been proposed. However, the epigenetic mechanisms underlying cellular rejuvenation are poorly understood. We studied the transcriptional changes in young, aged and mechanically rejuvenated fibroblasts using RNA-seq. The mechanically rejuvenated aged fibroblasts, that had reset their transcription to a younger cell state. In addition, the rejuvenated cells contractile properties were maintained over multiple cell passages. Taken together, our results provide a multi-scale characterization of the chromatin reorganization that accompanies cellular aging and rejuvenation.
Published in
Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging
Braunger JM, Cammarata LV, Sornapudi TR et al. · Aging cell 2024 · PMID 38062919 · doi:10.1111/acel.14056
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Also filed as BioProject PRJNA994507 and SRA study SRP449389. Searching any of these in the dataset finder brings you back here.

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