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Transcriptomic profile at single cell level of TIL-NK cells and tumor cells from tumor-bearing Reg-1fl/fl and Reg-1ΔNK mice

GSE237642 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/30 Platform GPL24247
Summary
The innate immune system can recognize tumor cells and coordinate with the adaptive immune system to initiate an anti-tumor response within the tumor microenvironment. To investigate the role of NK cells and their interaction with other immune cells in the anti-tumor immunity in Reg-1ΔNK. We subcutaneously injected B16F10 cells into Reg-1fl/fl and Reg-1ΔNK, followed by scRNA-seq analysis of the whole tumor cell suspension and sorted TIL-NK cells.
Published in
Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
Sun X, Nagahama Y, Singh SK et al. · Immunity 2024 · PMID 38821052 · doi:10.1016/j.immuni.2024.05.006
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Also filed as BioProject PRJNA996087 and SRA study SRP450227. Searching any of these in the dataset finder brings you back here.

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