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ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [FAIRE-seq]

GSE237957 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/12/26 Platform GPL24676
Summary
CIITA is the master regulator of MHC II gene expression and hence the adaptive immune response. CIITA expression itself is tightly regulated by three cell type-specific promoters, pI, pIII, and by pIV. Here, we demonstrate that the telomere-binding protein and transcriptional activator ZBTB48 directly binds to both the critical activating elements within CIITA pIII and is essential for its gene expression. ZBTB48 establishes open chromatin at CIITA pIII upstream of activating H3K4me3 modifications both priming CIITA transcription for IFNg-induction and ensuring constitutive expression in primary murine B cells. Hence, ZBTB48 acts as a molecular on-off-switch for B-cell-specific CIITA expression.
Published in
ZBTB48 is a priming factor regulating B-cell-specific CIITA expression
Rane G, Kuan VLS, Wang S et al. · The EMBO journal 2024 · PMID 39562739 · doi:10.1038/s44318-024-00306-y
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Also filed as BioProject PRJNA997298 and SRA study SRP450801. Searching any of these in the dataset finder brings you back here.

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