Human umbilical cord mesenchymal stem cell-derived exosomes deliver miRNA-451a targeting ATF2 to inhibit rheumatoid arthritis [RNA-seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Human umbilical cord mesenchymal stem cell-derived exosomes loaded miR-451a targets ATF2 to improve rheumatoid arthritisInternational immunopharmacology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE237991_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA997350 and SRA study SRP450833. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7657374 RASF, biol rep 1, NC1 group
- GSM7657375 RASF, biol rep 2, NC2 group
- GSM7657376 RASF, biol rep 3, NC3 group
- GSM7657377 RASF, biol rep 4, NC4 group
- GSM7657378 RASF, biol rep 5, NC5 group
- GSM7657379 RASF, biol rep 6, NC6 group
- GSM7657380 RASF, biol rep 1, hUCMSC-exos1 group
- GSM7657381 RASF, biol rep 2, hUCMSC-exos2 group
- GSM7657382 RASF, biol rep 3, hUCMSC-exos3 group
- GSM7657383 RASF, biol rep 4, hUCMSC-exos4 group
- GSM7657384 RASF, biol rep 5, hUCMSC-exos5 group
- GSM7657385 RASF, biol rep 6, hUCMSC-exos6 group
- GSE237993 Human umbilical cord mesenchymal stem cell-derived exosomes deliver miRNA-451a targeting ATF2 to inhibit rheumatoid arthritis. 27 samples shares mirna-451a, atf2, cell-derived, mesenchymal, rheumatoid, umbilical, targeting, arthritis
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- GSE283726 Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis 16 samples shares cell-derived, mesenchymal
- GSE298520 An engineered hypoxia-response promoter for human umbilical cord-derived mesenchymal stem cell-based therapeutics 15 samples shares mesenchymal, umbilical
- GSE274135 NANP Targeting Radio-sensitizes Glioblastoma through TNFR1 Sialylation-Driven Mesenchymal Shift 10 samples shares mesenchymal, targeting
- GSE262419 Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 4558 samples shares cell-derived
- GSE300470 A Stem and Progenitor Cell-Derived Gene Expression Signature is Prognostic for Survival in Myelofibrosis [RNA-Seq] 358 samples shares cell-derived
- GSE319722 Spatial dynamics links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in microsatellite stable colorectal cancer 117 samples shares mesenchymal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.