GEO series
Skeletal Muscle-On-A-Chip in Microgravity for Sarcopenia Modeling and Advanced Drug Screening
GSE238215
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2024/07/02
GPL20301
Summary
Microgravity has been shown to lead to both muscle atrophy and impaired muscle regeneration. The purpose was to study the efficacy of microgravity to model impaired muscle regeneration in an engineered muscle platform and then to demonstrate the feasibility of performing drug screening in this model. Engineered human muscle was launched to the International Space Station National Laboratories, where the effect of microgravity exposure for 7 days was examined by transcriptomics.
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Paper (PMID 39059375) ↗
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