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MCRS1 sensitizes pancreatic cancer to T cell immunity [cellline RNA]

GSE239358 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/14 Platform GPL24247
Summary
Pancreatic cancer is one of the deadliest cancers in humans and is yet refractory to immunotherapy. Identifying factors that can sensitize pancreatic cancer to immune cells may thus hold the key to improving immunotherapy efficacy. Herein, by pooled CRISPR activation screening, we find that the transcriptional regulator Mcrs1 (Microspherule protein 1) is pivotal to the immune sensitivity of pancreatic cancer cells, with elevated Mcrs1 expression inducing enhanced immune responses and tumor suppression in mice.
Published in
MCRS1 sensitizes T cell-dependent immunotherapy by augmenting MHC-I expression in solid tumors
Li X, Yi H, Jin Z et al. · The Journal of experimental medicine 2024 · PMID 39545935 · doi:10.1084/jem.20240959
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Also filed as BioProject PRJNA998895 and SRA study SRP451596. Searching any of these in the dataset finder brings you back here.

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