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Single-cell RNA sequencing Reveals Obesity-Induced Inhibition of Testosterone Production and Damage of Blood-Testis Barrier Integrity

GSE239391 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/03 Platform GPL24247
Summary
Obesity is accompanied by multiple known health risks and increased morbidity, and the prevalence of obesity continues to rise. Fertility in males of reproductive age is affected by the endocrine abnormalities and comorbidities associated with obesity, which has become a primary cause of male infertility. Single-cell RNA sequencing (scRNA-seq) of testes in obese individuals has not been done, so we chose to use this technique to study the mechanism of infertility in an obese mouse model.
Published in
Single-cell transcriptome atlas of testes from mice with high-fat diets
Cao W, Zhang Y, Qi J et al. · Scientific data 2024 · PMID 38834587 · doi:10.1038/s41597-024-03435-5
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Also filed as BioProject PRJNA999209 and SRA study SRP451787. Searching any of these in the dataset finder brings you back here.

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