tRNA m1A modification enhances anti-tumor immunity in macrophages by promoting translation of key interferon associated genes
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × BMDMs, TRMT61A-WT vs 3 × BMDMs, TRMT61A-KO vs 3 × TAMs, TRMT61A-WT vs 3 × TAMs, TRMT61A-KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- tRNA m(1)A modification orchestrates STING translation in macrophages to enhance antitumor immunity and CAR-macrophage immunotherapyCellular & molecular immunology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE239608_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA999752 and SRA study SRP452053. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7668517 BMDMs, TRMT61A-WT-1 BMDMs, TRMT61A-WT
- GSM7668518 BMDMs, TRMT61A-WT-2 BMDMs, TRMT61A-WT
- GSM7668519 BMDMs, TRMT61A-WT-3 BMDMs, TRMT61A-WT
- GSM7668520 BMDMs, TRMT61A-KO-1 BMDMs, TRMT61A-KO
- GSM7668521 BMDMs, TRMT61A-KO-2 BMDMs, TRMT61A-KO
- GSM7668522 BMDMs, TRMT61A-KO-3 BMDMs, TRMT61A-KO
- GSM7668818 TAMs, TRMT61A-WT-1 TAMs, TRMT61A-WT
- GSM7668819 TAMs, TRMT61A-WT-2 TAMs, TRMT61A-WT
- GSM7668820 TAMs, TRMT61A-WT-3 TAMs, TRMT61A-WT
- GSM7668821 TAMs, TRMT61A-KO-1 TAMs, TRMT61A-KO
- GSM7668822 TAMs, TRMT61A-KO-2 TAMs, TRMT61A-KO
- GSM7668823 TAMs, TRMT61A-KO-3 TAMs, TRMT61A-KO
- GSE286348 Macrophages foster anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction 18 samples shares macrophages, anti-tumor, immunity
- GSE278990 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity 73 samples shares anti-tumor, immunity
- GSE322775 Coordinated immune activation following KRAS inhibition reveals molecular pathways that potentiate and limit anti-tumor immunity 47 samples shares anti-tumor, immunity
- GSE316541 α2,6-Sialoglycan-regulated anti-tumor immunity of tumor-infiltrating CD8+ T cells in the tumor microenvironment [CD8+T] 27 samples shares anti-tumor, immunity
- GSE234974 Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity I 24 samples shares anti-tumor, immunity
- GSE245838 Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity [mouse scRNA-seq] 21 samples shares anti-tumor, immunity
- GSE324935 IFN-γ and TLR9 signaling reprogram tumor-associated macrophages to promote antitumor immunity in melanoma 20 samples shares macrophages, immunity
- GSE277610 Endothelial PD-L1 brakes CD8+ T cell exhaustion, empowering anti-tumor immunity in non-small cell lung cancer 17 samples shares anti-tumor, immunity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.