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Single-cell RNA sequencing analysis of Angiotensin II-induced mouse dissecting AAA samples

GSE239620 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/09/19 Platform GPL19057
Summary
Dissecting abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. Complex, complicated, and extremely heterogeneous diseases like dissecting AAAs severely limit our ability to understand it. A thorough understanding of cell types and signaling pathways associated with the initiation and progression of dissecting AAA is essential for the development of medical therapy. Single-cell RNA sequencing (scRNA-seq) was performed on the abdominal aortas from ApoE-/- mice at days 28 post-Angiotensin II-induced mouse dissecting AAAs. According to the Angiotensin II-induced dissecting AAA model described in this study, alterations in cellular subpopulations, fractions, and transcriptome profiles are present.
Published in
Single-cell RNA sequencing identifies interferon-inducible monocytes/macrophages as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk
Le S, Wu J, Liu H et al. · Cardiovascular research 2024 · PMID 38836630 · doi:10.1093/cvr/cvae117
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Also filed as BioProject PRJNA1000443 and SRA study SRP452273. Searching any of these in the dataset finder brings you back here.

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