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RNA sequencing of Tau overexpressing human SH-SY5Y cell line revels that Tau protein is able to alter global gene expression and chromatin structure

GSE239956 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/11 Platform GPL16791
Summary
Alzheimer’s disease and tauopathies are neurodegenerative disorders characterized by the alteration of neuronal homeostasis and aggregation of Tau protein. Tau is generally considered a protein involved in cytoskeletal stability and transport whose destabilization leads to neuronal dysfunction and death. Despite the knowledge about canonical roles of Tau, in recent years it has been observed that Tau is a key player in several neuronal functions. We previously described that Tau destabilization and nuclear delocalization alters the expression of glutamatergic genes mediating early neuronal damage. In this paper we propose that Tau is able to deeply affect the neuronal transcriptome and that its availability is associated to gene expression alterations occurring in developing intermediate AD phases. In addition, we identify the epigenetic pathway as strongly altered by Tau during AD progression.
Published in
Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer's disease stages
Siano G, Varisco M, Terrigno M et al. · Frontiers in cell and developmental biology 2024 · PMID 39830212 · doi:10.3389/fcell.2024.1459573
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Also filed as BioProject PRJNA1001822 and SRA study SRP453120. Searching any of these in the dataset finder brings you back here.

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