← BioTransfer GEO Dataset Finder
GEO series

scRNA-seq analysis of mouse tumor-infiltrating immune cells

GSE240048 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/30 Platform GPL24247
Summary
Cancer immuno-surveillance and response to checkpoint blockade therapy can be affected by multiple environmental factors, including nutrition. However, the direct effects of individual nutrients on anti-tumoral immune responses remain poorly understood. Here we addressed the impact of dietary ligands of Aryl Hydrocarbon receptor (AhR), a transcription factor activated by indoles and tryptophan catabolites generated through food digestion and microbiota metabolism. To this aim, we analyzed pre-clinical tumor models in mice fed on a diet naturally poor in AhR ligands, or the same diet enriched for Indole-3-carbinol, a phytonutrient cleaved by stomach enzymes into AhR agonists.
Published in
Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapy
De Juan A, Coillard A, Cros A et al. · Nature communications 2025 · PMID 41331250 · doi:10.1038/s41467-025-66854-x
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE240048_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1001981 and SRA study SRP453259. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.