Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [RNA-Seq]
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 24 samples: 12 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240496_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1003917 and SRA study SRP454291. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 12 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7698850 U937_DMSO_Rep1 U937_DMSO
- GSM7698851 U937_DMSO_Rep2 U937_DMSO
- GSM7698852 U937_FICZ_Rep1 U937_FICZ
- GSM7698853 U937_FICZ_Rep2 U937_FICZ
- GSM7698854 U937_JQ1_Rep1 U937_JQ1
- GSM7698855 U937_JQ1_Rep2 U937_JQ1
- GSM7698856 U937_COMBO_Rep1 U937_COMBO
- GSM7698857 U937_COMBO_Rep2 U937_COMBO
- GSM7698858 K562_EV_DMSO_Rep1 K562_EV_DMSO
- GSM7698859 K562_EV_DMSO_Rep2 K562_EV_DMSO
- GSM7698860 K562_EV_FICZ_Rep1 K562_EV_FICZ
- GSM7698861 K562_EV_FICZ_Rep2 K562_EV_FICZ
- GSM7698862 K562_EV_JQ1_Rep1 K562_EV_JQ1
- GSM7698863 K562_EV_JQ1_Rep2 K562_EV_JQ1
- GSM7698864 K562_EV_COMBO_Rep1 K562_EV_COMBO
- GSM7698865 K562_EV_COMBO_Rep2 K562_EV_COMBO
- GSM7698866 K562_OE_DMSO_Rep1 K562_OE_DMSO
- GSM7698867 K562_OE_DMSO_Rep2 K562_OE_DMSO
- GSM7698868 K562_OE_FICZ_Rep1 K562_OE_FICZ
- GSM7698869 K562_OE_FICZ_Rep2 K562_OE_FICZ
- GSM7698870 K562_OE_JQ1_Rep1 K562_OE_JQ1
- GSM7698871 K562_OE_JQ1_Rep2 K562_OE_JQ1
- GSM7698872 K562_OE_COMBO_Rep1 K562_OE_COMBO
- GSM7698873 K562_OE_COMBO_Rep2 K562_OE_COMBO
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing · shares leukemia
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing · shares leukemia
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing · shares leukemia
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing · shares leukemia
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing
- GSE240497 Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models 66 samples shares bet-targeting, ahr-elmsan1, preclinical, activation, nongenetic, suppresses, optimizes, leukemia
- GSE274680 Inflammation and lymphocyte activation during longitudinal progression to rheumatoid arthritis in at-risk individuals 243 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.