GEO series
BALF single-cell landscape in CARDS and non-ARDS patients at two time points
GSE240580
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2024/05/15
GPL24676
Summary
In this study, single-cell sequencing of the BALF of CARDS patients yielded the following results: (1) IL1B+ neutrophils were significantly increased in the BALF of CARDS patients with exacerbated disease, which was associated with poor prognosis of CARDS patients, and this type of neutrophils underwent fatty acid metabolism reprogramming in comparison with other types of neutrophils, which may be related to their high-inflammatory response. (2) IL1B+ neutrophils promoted TNF secretion from hyperinflammatory type M1 macrophages through a caspase-dependent pathway, suggesting that neutrophil-macrophage interactions play an important role in the mechanism of CARDS development.
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Paper (PMID 40999573) ↗
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