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Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span

GSE240858 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/01 Platform GPL24676
Summary
Early in ontogeny, gd T cells emerge from the thymus and directly seed peripheral tissues for in situ immunity, though their function in human tissues is not clear. Through analysis of gd T cells in mucosal and lymphoid tissues across the human lifespan, we reveal age- and site-specific differentiation states, functions, and dynamics. Pediatric tissues uniquely contain newly generated gd T cells with diverse repertoires, exhibiting tissue repair and effector functions. In adult tissues, gd T cells persist in lower frequencies, exhibiting highly expanded repertoires and cytolytic profiles. Over childhood, gd T cells convert to adult-like differentiation profiles in mucosal sites, revealing that gd T cells provide diverse recognition and functions for numerous antigenic challenges during early life but persist as terminally differentiated, innate-like cells thereafter.
Published in
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span
Gray JI, Caron DP, Wells SB et al. · Science immunology 2024 · PMID 38848342 · doi:10.1126/sciimmunol.adn3954
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Also filed as BioProject PRJNA1005589 and SRA study SRP455161. Searching any of these in the dataset finder brings you back here.

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