GEO series
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
GSE240874
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/04/15
GPL30173
Summary
Using CRISPR/Cas9 dropout screening, we identified superoxide dismutase-1 (SOD1) as a genetic dependency specific to PPM1D-mutant leukemia cells. We found that the mutant cells exhibited a compromised response to oxidative stress that can be rescued with SOD1 inhibitors. PPM1D-mutant fcells also exhibit significant genomic instability, highlighting the essential role of SOD1 in safeguarding against oxidative stress and DNA damage.
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Paper (PMID 37693622) ↗
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