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Single-nucleus RNA sequencing-based construction of a hippocampal neuron atlas in mice with epileptic memory impairment

GSE241349 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/18 Platform GPL24247
Summary
In this study, we utilized snRNA-seq to explore the transcriptional changes in hippocampal neurons of drug-resistant mice with memory disorder in epilepsy, and analyzed the inter-group heterogeneity of 20 subclasses of neurons, focusing on aspects such as cell communication, gene expressions, GO and KEGG enrichment analysis, and module gene set analysis. Our data provides a comprehensive transcriptomic description of the neuronal population affected by drug-resistant epileptic memory disorders. Further studies have shown that specific neuronal subpopulations impact synaptic plasticity through the regulation of relevant target genes by specific transcription factors.
Published in
Single-nucleus RNA sequencing-based construction of a hippocampal neuron atlas in mice with epileptic cognitive impairment
Ma JQ, Wang L, Zhang Y et al. · iScience 2024 · PMID 39635132 · doi:10.1016/j.isci.2024.111065
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Also filed as BioProject PRJNA1007729 and SRA study SRP456212. Searching any of these in the dataset finder brings you back here.

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