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Effect of knockdown of GRIK1 on gene expression dring glioblastoma progression

GSE242008 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/31 Platform GPL11154
Summary
Glioblastoma (GBM) is the most aggressive cancer in brain and contains a high mortality rate due to lack of effective treatment strategy. Molecular mechanisms of GBM characteristic invasive growth are urgently need to improve the poor prognosis.Here we reported that knockdown of GRIK1 retarded GBM cells growth and invasion.Moreover,high levels of GRIK1 were correlated to poor prognosis of GBM, consistent with The Cancer Genome Atlas (TCGA) database. Taken together, our study identified that GRIK1 is a novel and vital factor of GBM progression and may serve as a new biomarker for prognosis and therapy of GBM patients.
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Also filed as BioProject PRJNA1011188 and SRA study SRP457719. Searching any of these in the dataset finder brings you back here.

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