CarS2 mediated cysteine catabolism drives brown fat development and thermogenesis through persulfidating EBF2
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 22 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242244_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1012485 and SRA study SRP458233. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 10 replicated groups read from 22 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7756998 WT, S29BAT-1 WT, S29BAT
- GSM7756999 WT, S29BAT-2 WT, S29BAT
- GSM7757000 WT, S29BAT-3 WT, S29BAT
- GSM7757001 CarS2-AKO, S29BAT-4 CarS2-AKO, S29BAT
- GSM7757002 CarS2-AKO, S29BAT-5 CarS2-AKO, S29BAT
- GSM7757003 CarS2-AKO, S29BAT-6 CarS2-AKO, S29BAT
- GSM7757004 BAC cells, 0 day-1 BAC cells, 0 day
- GSM7757005 BAC cells, 0 day-2 BAC cells, 0 day
- GSM7757006 BAC cells, 4 day-1 BAC cells, 4 day
- GSM7757007 BAC cells, 4 day-2 BAC cells, 4 day
- GSM7757008 3T3-L1 cells, 0 day-2 3T3-L1 cells, 0 day
- GSM7757009 3T3-L1 cells, 0 day-3 3T3-L1 cells, 0 day
- GSM7757010 3T3-L1 cells, 6 day-1 3T3-L1 cells, 6 day
- GSM7757011 3T3-L1 cells, 6 day-2 3T3-L1 cells, 6 day
- GSM7841136 VH1 VH
- GSM7841137 VH2 VH
- GSM7841138 CH1 CH
- GSM7841139 CH2 CH
- GSM7841140 VE1 VE
- GSM7841141 VE2 VE
- GSM7841142 CE1 CE
- GSM7841143 CE2 CE
- GSE242243 CarS2 mediated cysteine catabolism drives brown fat development and thermogenesis through persulfidating EBF2 [BAC and L1 differ] 8 samples shares cars2, ebf2, persulfidating, thermogenesis, catabolism, mediated, cysteine, drives
- GSE245346 CarS2 mediated cysteine catabolism drives brown fat development and thermogenesis through persulfidating EBF2 [Cut & Tag] 8 samples shares cars2, ebf2, persulfidating, thermogenesis, catabolism, mediated, cysteine, drives
- GSE242242 CarS2 mediated cysteine catabolism drives brown fat development and thermogenesis through persulfidating EBF2 [AKO and wt Acute cold] 6 samples shares cars2, ebf2, persulfidating, thermogenesis, catabolism, mediated, cysteine, drives
- GSE297178 Targeting EBF2 condensates modulates adipose thermogenesis 90 samples shares ebf2, thermogenesis
- GSE288829 A Novel EBF2 Nonsense Variant Drives Adipose Tissue Fibrosis and Dysfunction in Partial Lipodystrophy Syndrome 6 samples shares ebf2, drives
- GSE253592 A Lactate-induced SREBF2-dependent genetic program drives an immunotolerant dendritic cell population during cancer progression [scRNAseq_mouse] 5 samples shares ebf2, drives
- GSE263446 SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice [ChIP-Seq] 4 samples shares ebf2, mediated
- GSE263445 SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice [RNA-Seq] 4 samples shares ebf2, mediated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.