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Improving blood vessel function in peripheral artery disease: endothelial-derived TRAIL generates stable microvessels in ischemia via TRAIL-R2

GSE242268 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/08/19 Platform GPL19057
Summary
Ischemia reduction in peripheral artery disease (PAD) through angiogenesis requires endothelial cell (EC) and pericyte interactions to form stable microvascular networks, but processes mediating this are disrupted in PAD. Patients with cardiovascular disease have suppressed levels of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). The contribution of endothelial cell (EC)-derived TRAIL to generating stable blood vessel networks and the impact of its receptors in PAD is unknown.We used scRNA-seq to identify molecular determinants that are altered in ischemic tissues of EC-specifc TRAIL KO mice vs littremate control mice, specifically looking at EC-pericyte interactions.
Published in
The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL
Cartland SP, Patil MS, Kelland E et al. · Science advances 2024 · PMID 39365855 · doi:10.1126/sciadv.adn8760
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Also filed as BioProject PRJNA1012805 and SRA study SRP458380. Searching any of these in the dataset finder brings you back here.

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