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Decoding the occupancy of RNA polymerase I on rDNA

GSE242318 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/09/10 Platform GPL23227
Summary
In order to deeply analyze the role of ribosome biogenesis associated proteins (RiBPs) in the development of breast cancer, we used chromatin immunoprecipitation combined with high-throughput sequencing (CHIP-seq) to detect the occupancy of RNA polymerase I on rDNA under the condition of RiBP knockout. In order to confirm the regulatory effect of RiBP on the transcriptional activity of pol I, the molecular mechanism of ribosome biogenesis associated proteins in promoting the malignant progression of breast tumors was further elaborated.
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Also filed as BioProject PRJNA1013095 and SRA study SRP458565. Searching any of these in the dataset finder brings you back here.

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