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Targeting oncogene-dependent TIM-3 induces T cell reprogramming thereby enhancing graft-versus-leukemia immunity - scRNAseq

GSE242334 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/07/24 Platform GPL24247
Summary
We use a mouse model for AML treatment in mice, based on injection of WEHI-3B AML cells followed by allogeneic transplantation of bone marrow and T cells. Allogeneic donor T cells will elicit anti-leukemic GVL effect. We want to decipher the importance of TIM-3 expression on T cells, therefore we used donor BM and donor T cells that contains a deletion for TIM-3 in CD8+ T cells (Havcr2fl/fl;E8icre/+). We performed single cell RNA sequencing and compared T cells isolated from Havcr2fl/fl;E8icre/+ or Havcr2fl/fl (control).
Published in
Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice
Talvard-Balland N, Braun LM, Dixon KO et al. · The Journal of clinical investigation 2024 · PMID 38916965 · doi:10.1172/JCI177460
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Also filed as BioProject PRJNA1013117 and SRA study SRP458632. Searching any of these in the dataset finder brings you back here.

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