Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated Responses
RNA-seq (gene expression) · human · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 19 samples: 19 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibiting the P2Y(12) Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated ResponsesJACC. Basic to translational science · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242369_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1013349 and SRA study SRP458880. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 19 sample titles: 19 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7761805 1. 3817A DMSO control 24 hours
- GSM7761806 2. 3817B Aspirin treatment 24 hours
- GSM7761807 3. 3817C AZD1283 treatment 24 hours
- GSM7761808 4. 3817D Aspirin + AZD1283 treatment 24 hours
- GSM7761809 5. 3819A DMSO control 24 hours
- GSM7761810 6. 3819B Aspirin treatment 24 hours
- GSM7761811 7. 3819C AZD1283 treatment 24 hours
- GSM7761812 8. 3819D Aspirin + AZD1283 treatment 24 hours
- GSM7761813 9. 3824A DMSO control 24 hours
- GSM7761814 10. 3824B Aspirin treatment 24 hours
- GSM7761815 11. 3824C AZD1283 treatment 24 hours
- GSM7761816 12. 3824D Aspirin + AZD1283 treatment 24 hours
- GSM7761817 13. 3702A DMSO control 24 hours
- GSM7761818 14. 3702B Aspirin treatment 24 hours
- GSM7761819 15. 3702C AZD1283 treatment 24 hours
- GSM7761820 16. 3702D Aspirin + AZD1283 treatment 24 hours
- GSM7761821 17. 3819E PBS control 24 hours
- GSM7761822 20. 3824E PBS control 24 hours
- GSM7761823 23. 3702E PBS control 24 hours
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- GSE289971 m6A Methylation Suppresses anti-tumour immune responses in Colorectal Cancers by Inhibiting Double-stranded RNA accumulation from Alu Repeats [RNA-Seq1] 16 samples shares inhibiting, suppresses
- GSE310060 Efficient Chemical Reprogramming of Human T Cells into Functional Megakaryocytes and Platelets 24 samples shares megakaryocytes, platelets
- GSE216593 Generation of megakaryocytes and functional platelets from human embryonic stem cells 18 samples shares megakaryocytes, platelets
- GSE260954 Effect of iPSC-derived megakaryocytes and platelets on gene expression of HUVEC 12 samples shares megakaryocytes, platelets
- GSE336445 Androgen Receptor-Driven RASSF3 Upregulation Promotes CKD Progression by Inhibiting Gαs/Gq Activity to Mediate Metabolic Reprogramming [DT] 8 samples shares inhibiting, receptor
- GSE268326 Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression [RNA-seq] 6 samples shares inhibiting, suppresses
- GSE307425 Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity 6 samples shares inhibiting, suppresses
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.