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Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis

GSE242510 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/15 Platform GPL24247
Summary
Single-cell RNA sequencing (scRNA-seq) was performed to investigate fibroblast–myeloid cell crosstalk in lung fibrosis. The dataset includes murine lung macrophage–fibroblast cocultures or fibroblast monocultures, with macrophages derived from WT mice and fibroblasts from either WT or fibroblast-specific P2rx4 knockout (Pdgfrb-Cre: P2rx4 f/f) mice 7 days after bleomycin injury. Cells were captured using the Fluent Biosciences PIPseq platform. Data include gene–cell count matrices and support the study “Myeloid–mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis” (Yadav et al., 2025).
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Direct links to NCBI, no account and no request form: the whole study as GSE242510_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1013615 and SRA study SRP458943. Searching any of these in the dataset finder brings you back here.

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