GEO series
Gene expression profiling of human induced pluripotent stem cell (hiPSC)-derived chondrospheroids
GSE242523
Homo sapiens
Expression profiling by high throughput sequencing
15 samples
2024/08/08
GPL30173
Summary
Differentiated chondrocytes from human induced pluripotent stem cells (hiPSCs) have the potential to permanently restore damaged cartilage in arthritic joints, yet chondrocyte hypertrophy is a major barrier for translational therapy. We developed a serum-free hiPSC differentiation strategy that inhibited, then activated BMP signaling in a purified SOX9+ subpopulation that naturally detaches from monolayer cultures (termed “chondrospheroids”). Transcriptional profiles of chondrospheroids at days 14, 28, and 42 were measured using bulk RNA sequencing, with hiPSC and sclerotome cells included as controls.
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Paper (PMID 39193188) ↗
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