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Global transcriptional profiles of primary and secondary cellular senescence in vivo by oncogene-induced senescence (OIS) and stress-induced senescence (SIS) [scRNA-seq]

GSE242705 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/19 Platform GPL21103
Summary
The physiological roles of cellular senescence in vivo are largely unknown. We report primary and secondary senescence-induced transcriptional alteration by oncogene-induced senescence (OIS, ERK activation) and stress-induced senescence (SIS, p38 activation) of mouse hepatocytes. Our analyses revealed that each senescence-induced cell displays different transcriptional profiles explaining various known senescent properties.
Published in
Characterizing primary and secondary senescence in vivo
Sogabe Y, Shibata H, Kabata M et al. · Nature aging 2025 · PMID 40646305 · doi:10.1038/s43587-025-00917-y
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Also filed as BioProject PRJNA1014391 and SRA study SRP459274. Searching any of these in the dataset finder brings you back here.

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