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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [scRNAseq]

GSE242966 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/07/01 Platform GPL24676
Summary
Glioblastomas are the most common malignant brain tumours in adults; they are highly aggressive, heterogeneous and plastic. We have identified METTL7B as an essential regulator of lineage specification in glioblastoma, with impact on both tumour size and invasiveness in in vivo models. Single cell transcriptomic analysis of these tumours and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B identified a regulatory role for the gene in the neural stem cells to astrocyte differentiation trajectory. Mechanistically, METTL7B downregulates the expression of key neuronal differentiation players, including SALL2, via DNA methylation and post-translational modifications of histone marks.
Published in
Lineage specification in glioblastoma is regulated by METTL7B
Constantinou M, Nicholson J, Zhang X et al. · Cell reports 2024 · PMID 38848215 · doi:10.1016/j.celrep.2024.114309
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Also filed as BioProject PRJNA1015630 and SRA study SRP459961. Searching any of these in the dataset finder brings you back here.

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