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RNA-seq analysis after STXBP5 overexpression or STXBP5 knockdown in HA-progerin HEK293 cells

GSE243095 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/09/14 Platform GPL16791
Summary
Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by a mutant LMNA called progerin. To determine the mechanism of STXBP5 on progerin, we over expressed STXBP5 or knocked down STXBP5 in HA-progerin HEK293 cells, then analyzed the effect on the expression of coding genes. In this study, we identified STXBP5 as an influencing factor for HA-progerin HEK293 cells. Lowering the expression of STXBP5 may be a new therapeutic strategy for treating age-related phenotypes in HGPS.
Published in
The syntaxin-binding protein STXBP5 regulates progerin expression
Qi H, Wu Y, Zhang W et al. · Scientific reports 2024 · PMID 39379476 · doi:10.1038/s41598-024-74621-z
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Also filed as BioProject PRJNA1016346 and SRA study SRP460349. Searching any of these in the dataset finder brings you back here.

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