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Immune polarization of type 1 and type 2 human eosinophils

GSE243490 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/15 Platform GPL20301
Summary
Eosinophils have specific immune phenotypes in type 2 and type 1 environments both in vitro and in translational models of disease in vivo. RNA sequencing was completed on human blood eosinophils cultured with cytokines that represent a Th2 (IL-33, IL-4, GM-CSF) or Th1 (TNFα/IFNγ)-associated environment cytokines.
Published in
IRF1 Is an upstream regulatory transcription factor of eosinophils in type 1 environments
Nazaroff CD, Kienzl M, Schutte CA et al. · The Journal of allergy and clinical immunology 2026 · PMID 41391829 · doi:10.1016/j.jaci.2025.11.011
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Also filed as BioProject PRJNA1018580 and SRA study SRP461510. Searching any of these in the dataset finder brings you back here.

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