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Single-cell transcriptomic characterization of immune cells from livers of wild type and ATF6 transgenic mice

GSE243826 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/11/05 Platform GPL13112
Summary
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF6α) remains unclear. We isolated CD45+ cells from livers of wild type and hepatocyte-specific nATF6 overexprerssion mice for scRNAseq to decrible the the immune cell population.
Published in
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance
Li X, Lebeaupin C, Kadianaki A et al. · Nature 2026 · PMID 41639449 · doi:10.1038/s41586-025-10036-8
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Also filed as BioProject PRJNA1020117 and SRA study SRP462702. Searching any of these in the dataset finder brings you back here.

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