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Single-Cell multi-omics reveals disrupted gene regulatory landscape and cell differentiation by Wilms tumor-associated ENL mutation in the developing kidney (ChIP-Seq)

GSE243866 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 5 samples Submitted 2024/05/27 Platform GPL21697
Summary
ENL is an epigenetic acetylation reader and represents the most frequently mutated epigenetic regulator in Wilms tumor. In this study, we established an in vivo mouse model with the ENL hotspot mutation Enl-T1. Here we performed ChIP sequencing (ChIP-seq) analysis for human embryonuc kidney cell line HEK293 with ENL-WT or T1 to study the genomic binding site alterations induced by ENL mutation and whether those alterations can be rescued by treating the cells with the specific ENL inhibitor TDI-11055.
Published in
Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape
Song L, Li Q, Xia L et al. · Nature communications 2024 · PMID 39009564 · doi:10.1038/s41467-024-50171-w
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Also filed as BioProject PRJNA1020185 and SRA study SRP462787. Searching any of these in the dataset finder brings you back here.

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