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Dietary supplement vanadyl sulfate selectively eliminates senescent cells

GSE243912 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/09/22 Platform GPL24676
Summary
During human evolution, lifestyles including dietary choices have had a major impact on shaping of human physiology and health, including aging. However, the underlying mechanisms remain largely unknown. Here, we use a blood nutrient compound library-based screening approach to demonstrate that dietary supplement vanadyl sulfate (VS) selectively induces cell death in senescent cells and ameliorates phenotypes of aging and age-related disorders in vivo. Integrated chemical biology and multi-omics studies reveal that senescent cells are specifically sensitive to VS due to reduced cysteine reactivity with accumulated glutathione disulfide. VS selectively inactivates reactive cysteines on proteins to induce formation of incorrect disulfide bonds in senescent cells with imbalanced cellular redox status, causing aberrant protein misfolding and aggregation and eventual cell death. Our findings uncover a new senolytic mechanism to mitigate age-related disorders and reshape human physiology.
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Also filed as BioProject PRJNA1020558 and SRA study SRP462894. Searching any of these in the dataset finder brings you back here.

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