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Single cell profiling of lichen planus identifies type I interferon response and potential therapeutic targeting

GSE243940 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/04/02 Platform GPL24676
Summary
Cutaneous lichen planus (LP) is an inflammatory skin disease characterized by an interface dermatitis with lymphocyte infiltration and keratinocyte cell-death. Previous studies suggest that LP inflammation is dominated by a type I immune response involving IFN-g but its pathogenesis remains not fully elucidated yet. To investigate the inflammatory mechanisms underlying LP, we performed single-cell RNA sequencing on LP compared with healthy control skins. We demonstrate that LP skin is imprinted by a type I interferon (IFN-I)-rich environment. While all immune cells are imbued with this interferon signature, we highlight unique subsets of inflammatory keratinocytes and fibroblasts highly influenced by IFN-I.
Published in
Single-Cell Profiling of Lichen Planus Reveals Type I IFN Response Triggering the Interface Dermatitis Reaction
Grolleau C, Poisot T, Roux C et al. · The Journal of investigative dermatology 2025 · PMID 40499747 · doi:10.1016/j.jid.2025.04.043
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Also filed as BioProject PRJNA1020773 and SRA study SRP462992. Searching any of these in the dataset finder brings you back here.

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