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Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection

GSE244026 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/12 Platform GPL24676
Summary
We aimed to study impact of CDC-like kinase (CLK) inhibitor CaNDY on OAS1 splicing manipulation. Our data indicates CaNDY treatment induces switching of OAS1 splice isoforms to provide an increased resistance to SARS-CoV-2 infection.
Published in
Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection
Iida K, Ajiro M, Nakano-Kobayashi A et al. · BMC biology 2025 · PMID 40025489 · doi:10.1186/s12915-025-02173-3
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Also filed as BioProject PRJNA1021066 and SRA study SRP463172. Searching any of these in the dataset finder brings you back here.

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