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Investigation of PSF and p53 binding sites in prostate ccancer cells

GSE244040 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/09/01 Platform GPL24676
Summary
Proline- and glutamine-rich (PSF) has been identified as an important driver of aggressive cancers, in which PSF-RNA interactions promotes the expression of numerous oncogenic transcripts by modulating epigenetic and splicing systems. To develop small compounds targeting PSF as next generation therapeutic agents for hormone therapy refractory cancers, we performed small molecule library screen and identified the compound designated as No.10-3 as a potent PSF inhibitor. We further describe another small molecule C-30, an improved analog of No.10-3. PSF inhibits p53 epression in prostate cancer cells by epigenetic regulation. We then performed ChIP-seq analysis to determined PSF and p53 binding regions.
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Also filed as BioProject PRJNA1021150 and SRA study SRP463165. Searching any of these in the dataset finder brings you back here.

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