Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells [Batch1]
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 12 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active diseaseNature microbiology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244312_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1022394 and SRA study SRP463836. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 12 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7813387 MS_LCL4_1 MS_LCL4
- GSM7813388 MS_LCL4_2 MS_LCL4
- GSM7813389 MS_LCL6_1 MS_LCL6
- GSM7813390 MS_LCL6_2 MS_LCL6
- GSM7813391 MS_LCL5_1 MS_LCL5
- GSM7813392 MS_LCL5_2 MS_LCL5
- GSM7813393 MS_LCL2_1 MS_LCL2
- GSM7813394 MS_LCL2_2 MS_LCL2
- GSM7813395 MS_LCL1_2 MS_LCL1
- GSM7813396 MS_LCL1_1 MS_LCL1
- GSM7813397 MS_LCL3_1 MS_LCL3
- GSM7813398 MS_LCL3_2 MS_LCL3
- GSM7813399 HC_LCL3_1 HC_LCL3
- GSM7813400 HC_LCL3_2 HC_LCL3
- GSM7813401 HC_LCL4_1 HC_LCL4
- GSM7813402 HC_LCL4_2 HC_LCL4
- GSM7813403 HC_LCL6_1 HC_LCL6
- GSM7813404 HC_LCL6_2 HC_LCL6
- GSM7813405 HC_LCL5_1 HC_LCL5
- GSM7813406 HC_LCL5_2 HC_LCL5
- GSM7813407 HC_LCL1_1 HC_LCL1
- GSM7813408 HC_LCL1_2 HC_LCL1
- GSM7813409 HC_LCL2_1 HC_LCL2
- GSM7813410 HC_LCL2_2 HC_LCL2
- GSE267750 TBX21+CD21loCXCR3+B cell expansion with an EBV-associated phenotype in clinically isolated syndrome conversion to multiple sclerosis 32 samples shares ebv, sclerosis, multiple
- GSE279972 Foamy microglia link oxylipins to disease progression in multiple sclerosis 109 samples shares sclerosis, multiple
- GSE330029 Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis [BulkRNAseq] 108 samples shares sclerosis, multiple
- GSE283092 Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis 96 samples shares sclerosis, multiple
- GSE290554 Mapping the Molecular Signature of Progressive Multiple Sclerosis 94 samples shares sclerosis, multiple
- GSE261258 Human regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in Multiple Sclerosis. 89 samples shares sclerosis, multiple
- GSE266132 Impact of the Multiple Sclerosis associated genetic variant CD226 Gly307Ser on human CD8 T cell functions 80 samples shares sclerosis, multiple
- GSE290450 Mapping the Molecular Signature of Progressive Multiple Sclerosis [194017] 78 samples shares sclerosis, multiple
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.