Binding Changes in Chromatin Factors Upon Targeted XPO1 Inhibition in T Cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 20 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 18 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- C646 degrades Exportin-1 to modulate p300 chromatin occupancy and functionCell chemical biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244396_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1022781 and SRA study SRP464003. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 20 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7814686 Jurkat cells, 24 hrs, IgG control antibody 1
- GSM7814687 Jurkat cells, 24 hrs, XPO1 antibody
- GSM7814688 Jurkat cells, 24 hrs, C646, XPO1 antibody
- GSM7814689 Jurkat cells, 24 hrs, p300 antibody
- GSM7814690 Jurkat cells, 24 hrs, C646, p300 antibody
- GSM7814691 Jurkat cells, 24 hrs, IgG control antibody 2
- GSM7814692 Jurkat cells, 8 hrs, XPO1 antibody
- GSM7814693 Jurkat cells, 8 hrs hours, S109, XPo1 antibody
- GSM7814694 Jurkat cells, 24 hours, p300 antibody
- GSM7814695 Jurkat cells, 24 hours, C646, p300 antibody
- GSM7814696 Jurkat cells, 8 hrs, S109, p300 antibody
- GSM7876476 Jurkat XPO1 C528S cells, 24 hrs, IgG control antibody [IgG_C528S]
- GSM7876477 Jurkat XPO1 C528S cells, 24 hrs, XPO1 antibody [XPO1_C528S]
- GSM7876478 Jurkat XPO1 C528S cells, 24 hrs, 10 uM C646, XPO1 antibody [XPO1_C646_C528S]
- GSM7876479 Jurkat XPO1 C528S cells, 24 hrs, p300 antibody [p300_C528S]
- GSM7876480 Jurkat XPO1 C528S cells, 24 hrs, 10 uM C646, p300 antibody [p300_C646_C528S]
- GSM8119566 Jurkat cells, basal state (no activation), 8 hours, p300 antibody, rep1
- GSM8119567 Jurkat cells, basal state (no activation), 8 hours, p300 antibody, rep2
- GSM8119568 Jurkat cells, PMA Ionomycin, 8 hours, p300
- GSM8119569 Jurkat cells, PMA Ionomycin + 1 uM SP100030, 8 hours, p300
- GSE254244 Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes 112 samples shares inhibition, chromatin
- GSE171817 SUMOylation Regulates Super-Enhancers Through Transcription Factor TFAP2C Binding on Chromatin 30 samples shares chromatin, binding
- GSE193413 Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth [Hi-C] 28 samples shares inhibition, chromatin
- GSE204912 Mapping genotypes to chromatin accessibility profiles in single cells 55 samples shares chromatin
- GSE142751 Genome-wide maps of chromatin state in 142 cancer cell lines [cell line] 855 samples shares chromatin
- GSE270126 Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency. 219 samples shares chromatin
- GSE301505 Mutual Antagonism Between PRC1 Condensates and SWI/SNF in Chromatin Regulation 210 samples shares chromatin
- GSE327821 Single-molecule, single-cell profiling of linked chromatin states [Single_cell_CoCUT&Tag] 200 samples shares chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.