GEO series
KDM6A Regulates Immunogenicity of Multiple Myeloma (ChIP-seq)
GSE244510
Mus musculus; Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
24 samples
2024/10/01
GPL24676GPL24247
Summary
We created isogenic mutiple myeloma and mouse embryonic fibroblast cell lines disrupted for KDM6A using CRISPR editing and Cre-mediated deletion. To detect KDM6A we inserted a dual HA tag sequence into the C-terminal of KDM6A by CRISPR-mediated editing. We also created one isogenic cell line harboring a jmjD-dead KDM6A where 2 amino acids essential for KDM6A enzymatic activity, H1146 and E1148 , were replaced with alanine residues
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