GEO series
WNK2 regulates the response to hyperosmotic stress in chondrocytes
GSE244584
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2024/08/01
GPL24676
Summary
How chondrocytes of the synovial joint sense and respond to hyperosmotic stress to maintain joint homeostasis over time is undetermined. The With-No-Lysine (K) (WNK) protein kinases are major intracellular sensors of hyperosmotic stress that respond by regulating ion channel activity and signaling pathways. To determine if WNK2 is a hyperosmotic sensor in chondrocytes and to identify the genes and pathways regulated by WNK2, we examined the molecular response of chondrocytes to WNK2 overexpression and hyperosmotic stress.
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