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LncRNA SLC7A11-AS1 suppresses ferroptosis in hepatocellular carcinoma to promote tumorigenesis

GSE244762 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/17 Platform GPL24676
Summary
LncRNAs are playing essential roles in epigenetic regulation, mRNA translation, and protein modification. However, the function of SLC7A11-AS1, an antisense lncRNA derived from the solute carrier family 7 member 11 (SLC7A11) gene, remains incompletely known. In this study, we utilized shRNA technology to knock down SLC7A11-AS1 in HepG2 cells, aiming to investigate the role of SLC7A11-AS1 in hepatocellular carcinoma. RNA-seq results revealed that there were 2536 differentially expressed genes upon SLC7A11-AS1 knockdown.
Published in
Identification of SLC7A11-AS1/SLC7A11 pair as a ferroptosis-related therapeutic target for hepatocellular carcinoma
Yuan X, Wang Y, Jiao S et al. · Journal of cellular and molecular medicine 2024 · PMID 38984939 · doi:10.1111/jcmm.18496
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Also filed as BioProject PRJNA1024514 and SRA study SRP464785. Searching any of these in the dataset finder brings you back here.

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