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Tumor suppressive role of CELF2 in skin tumorignesis

GSE244862 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/26 Platform GPL20301
Summary
To investigate the function of CELF2 in non-melanoma skin cancer, we performed immunofluorescence staining studies and found lower CELF2 expression in human squamous cell carcinoma (SCC) tumors than in adjacent normal skin. CELF2 expression was also downregulated during both ultraviolet light- and chemical-induced skin tumorigenesis in mice, suggesting that CELF2 loss might promote skin cancer development. By using shRNA-mediated knockdown (KD) of CELF2 expression, we showed that CELF2 deficiency significantly increased SCC cell proliferation and colony growth in vitro and increased SCC tumor growth in a xenograft mouse model. Although control SCC cells were sensitive to anticancer drugs such as doxorubicin, CELF2-KD SCC cells were resistant to drug-induced tumor growth retardation. Through RNA-seq analysis, we identified that CELF2 loss led to activation of KRT80 and GDF15, which could confer growth and survival advantages to CELF2-deficient SCC cells.
Published in
Loss of CELF2 promotes skin tumorigenesis and increases drug resistance
Sah B, Singh J, Shen Y et al. · International journal of dermatology 2025 · PMID 38887832 · doi:10.1111/ijd.17295
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Also filed as BioProject PRJNA1025023 and SRA study SRP464919. Searching any of these in the dataset finder brings you back here.

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