Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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Also filed as BioProject PRJNA132611. Searching any of these in the dataset finder brings you back here.

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• GSE30339 IDH1 Mutation is a Master Regulator of Epigenomic Remodeling and is Sufficient to Establish the Glioma Hypermethylator Phenotype 192 samples shares idh1, phenotype
• GSE15688 Acquired mutations in TET2 are common in myelodysplastic syndromes 122 samples shares tet2, mutations
• GSE30835 mRNA expression data of tumor samples with/without IDH1/2 mutations and of controls 27 samples shares idh1, mutations
• GSE280581 Intragenic Epigenetic Deregulation by IDH2 Mutations Synergizes with SRSF2 Mutations Causing Mis-splicing of Key Transcriptional Regulators [RNA-seq] 20 samples shares idh2, mutations
• GSE319667 Tet2 deficiency alters CD4+ T-cell function and promotes T-cell lymphoma with a TFH-cell immunophenotype. 6 samples shares tet2, phenotype
• GSE210435 TET2 Mutant Clonal Hematopoiesis Enhances Severity of COVID-19 Related Cytokine Release Syndrome and is Associated with Increased Mortality. 363 samples shares tet2
• GSE261324 NF-κB- and TET2-mediated macrophage reprogramming overrides the anti-inflammatory effects of hypoxia and improves responses in human cancer 88 samples shares tet2
• GSE45200 An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells 77 samples shares idh1

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