A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals major role of BAX in BH3 mimetics response
RNA-seq (gene expression) · human · 138 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 138 samples: 42 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimeticsBlood · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE245163_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1027275 and SRA study SRP465600. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 137 samples.
How we read this: 42 replicated groups read from 138 sample titles; they account for 137 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7835289 MM_3 MM
- GSM7835290 MM_5 MM
- GSM7835291 MM_9 MM
- GSM7835292 MM_10 MM
- GSM7835293 MM_13 MM
- GSM7835294 MM_14 MM
- GSM7835295 MM_15 MM
- GSM7835296 MM_17 MM
- GSM7835297 MM_18 MM
- GSM7835298 MM_31 MM
- GSM7835299 MM_33 MM
- GSM7835300 MM_34 MM
- GSM7835301 MM_35 MM
- GSM7835302 MM_38 MM
- GSM7835303 MM_39 MM
- GSM7835304 MM_41 MM
- GSM7835305 MM_42_replicate 2 MM_42
- GSM7835306 MM_42_replicate 1 MM_42
- GSM7835307 MM_43 MM
- GSM7835308 MM_51 MM
- GSM7835309 MM_56 MM
- GSM7835310 MM_58_replicate 2 MM_58
- GSM7835311 MM_58_replicate 1 MM_58
- GSM7835312 MM_62 MM
- GSM7835313 MM_63 MM
- GSM7835314 MM_64 MM
- GSM7835315 MM_65 MM
- GSM7835316 MM_72 MM
- GSM7835317 MM_73 MM
- GSM7835318 MM_74_replicate 1 MM_74
- GSM7835319 MM_74_replicate 2 MM_74
- GSM7835320 MM_75 MM
- GSM7835321 MM_76_replicate 2 MM_76
- GSM7835322 MM_76_replicate 1 MM_76
- GSM7835323 pPCL_77
- GSM7835324 sPCL_78 sPCL
- GSM7835325 sPCL_79 sPCL
- GSM7835326 sPCL_80 sPCL
- GSM7835327 sPCL_81 sPCL
- GSM7835328 sPCL_82 sPCL
+ 98 more — browse all 138 samples with per-sample file links →
- GSE290621 Quadruple adenine base edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease engineered T cells [RNA-seq] 33 samples shares crispr, cas9
- GSE301632 Genome-wide CRISPR-Cas9 knockout screening identifies NUDCD2 depletion as sensitizer for bortezomib, carfilzomib and ixazomib in multiple myeloma. 27 samples shares crispr, cas9
- GSE303100 Dissecting Resistance to CDK4/6 Inhibition in Experimental Glioma via Genome-wide CRISPR-Cas9 Screening 24 samples shares crispr, cas9
- GSE248671 Gene expression analysis of human sickle cell disease (SCD) and healthy donor (HD) CD34+ hematopoietic stem/progenitor cells (HSPCs) treated with CRISPR/Cas9 targeting the HBG promoters or untreated samples 24 samples shares crispr, cas9
- GSE240468 Silencing of NFYC-AS1 by Gapmer antisense oligonucleotides and CRISPR/Cas9 TSS deletion. 23 samples shares crispr, cas9
- GSE283554 A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics 22 samples shares crispr, cas9
- GSE226978 RNA-Sequencing Analysis of LNCaP Wildtype (WT) and RB-p53 CRISPR-Cas9 Double Knockout (DKO) Cells Treated with Enzalutamide 16 samples shares crispr, cas9
- GSE319117 Simultaneous orthogonal cell engineering by a single CRISPR-Cas9 polyfunctional editor [RNA-seq T-cells B2M/TET2/TGFBR2] 14 samples shares crispr, cas9
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.