GEO series
A Genome Scale Transcriptional Regulatory Model of the Human Placenta
GSE245395
Homo sapiens
Expression profiling by high throughput sequencing
104 samples
2024/07/03
GPL11154
Summary
Gene regulation is essential to placental function and fetal development. We built a genome-scale transcriptional regulatory network (TRN) of the human placenta using digital genomic footprinting and transcriptomic data. We integrated 475 transcriptomes and 12 DNase hypersensitivity datasets from placental samples to globally and quantitatively map transcription factor (TF)-target gene interactions. We performed siRNA knockdowns of 4 TFs and achieved concordance between the predicted gene targets in our TRN.
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Paper (PMID 38941464) ↗
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