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Genome-wide gene expression profiling with RNA-seq following VPA treatment in HEK293 cells

GSE245856 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/02 Platform GPL28038
Summary
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor induces epigenetic changes through histone hyperacetylation which could affect gene expression. To determine the effects of VPA on gene expression changes, we performed RNA-seq on untreated and VPA-treated HEK293T cells. Differentially-expressed genes (DEGs) induced by VPA exposure were enriched in signaling processes, regulation of ion transport and extracellular matrix organization, known to be associated with HDAC activities.
Published in
Image-based epigenetic profiling with deep learning and high-speed super-resolution microscopy
Wang Y, Ab Ghani NS, Dutta M et al. · Epigenetics & chromatin 2026 · PMID 41764479 · doi:10.1186/s13072-026-00662-5
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Also filed as BioProject PRJNA1030281 and SRA study SRP467502. Searching any of these in the dataset finder brings you back here.

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